SCIENCE

FESPIXON® Cream

 

  • Brand Name
FESPIXON® Cream
  • Indications
Diabetic Foot Ulcers (DFU)
  • Mechanism of Action
  • Inhibits inflammation
  • Regulates the generation of collagen
  • Promotes the regeneration of damaged cells
  • Promotes the proliferation of human keratinocytes
  • Reduce inflammatory M1 macrophages, stimulate adipose precursor cells to secrete GCSF and CXCL3, and increase repairing M2a/M2c macrophages, thereby promote complete wound healing. The mechanism of action studies can be referred to JID Innovations (2022).
  • Taiwan FDA Approval Number

060827

  • Singapore HSA Approval Number
SIN16683P
  • Malaysia NPRA Approval Number 
MAL23076025B
  • China NMPA Approval Number 
ZC20230001 (Approved generic name: Xianglei Tangzu Gao)
  • Indonesia BPOM Approval Number 
TI247049901
  • Research Publication/ Abstract
More Infromation

You are encouraged to report negative side effects of prescription drugs to:
Phone: 0800-258-688
Mail: PV.PMS@onenessbio.com.tw

Prescription medications must be used only under the direction of a licensed physician. If you have any health concerns, please seek medical advice from a qualified healthcare provider. Find the closest hospital for medical care.

 

Package Insert Download

 

  • Brand Name
FESPIXON® Cream
  • Indications
Diabetic Foot Ulcers (DFU)
  • Mechanism of Action
  • Inhibits inflammation
  • Regulates the generation of collagen
  • Promotes the regeneration of damaged cells
  • Promotes the proliferation of human keratinocytes
  • Reduce inflammatory M1 macrophages, stimulate adipose precursor cells to secrete GCSF and CXCL3, and increase repairing M2a/M2c macrophages, thereby promote complete wound healing. The mechanism of action studies can be referred to JID Innovations (2022).
  • Taiwan FDA Approval Number

060827

  • Singapore HSA Approval Number

SIN16683P

  • Malaysia NPRA Approval Number

MAL23076025B

  • China NMPA Approval Number 
  • Indonesia BPOM Approval Number 

TI247049901

  • Research Publication/ Abstract

Click Here

 

You are encouraged to report negative side effects of prescription drugs to:
Phone: 0800-258-688
Mail:
PV.PMS@onenessbio.com.tw

Prescription medications must be used only under the direction of a licensed physician. If you have any health concerns, please seek medical advice from a qualified healthcare provider. Find the closest hospital for medical care.


Package Insert Download

Mechanism of Action

Novel Mechanism Promotes Healing by Regulating M1/M2 Macrophages
and Rebalancing the Wound Microenvironment

Inhibit pro-inflammatory M1 φ and stimulate adipose precursor cells to secrete GCSF and CXCL3 to increase repairing M2a/M2c φ

Reference: Restoring Pro-healing/remodeling-associated M2a/c Macrophages using ON101 Accelerates Diabetic Wound Healing, JID Innovations (2022);2:100138, doi: https://doi.org/10.1016/j.xjidi.2022.100138.

 

Superior Efficacy to Current Standard Care

 

Incidence of Complete Healing - Full Analysis Set

FESPIXON® group achieved significant efficacy vs standard care (AQUACEL® Hydrofiber®) group (p=0.0001)

The Cumulative Rate of Complete Healing

The healing trend of FESPIXON® remained steady and robust at each observation time point.  

Incidence of Complete Healing - Full Analysis Set

FESPIXON® group achieved significant efficacy vs standard care (AQUACEL® Hydrofbier®) group (p=0.0001)

The Cumulative Rate of Complete Healing

The healing trend of FESPIXON® remained steady and robust at each observation time point.  

Reference: Effect of a Novel Macrophage-Regulating Drug on Wound Healing in Patients With Diabetic Foot Ulcers, JAMA Netw Open. 2021;4(9):e2122607, doi:10.1001/jamanetworkopen.2021.22607.

 

/* 以上是表格-计算机版RWD */

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