SCIENCE

PIPELINE

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Research Code Therapeutic Area Indication Pre-Clinical Phase I Phase II Phase III NDA Market More
  • ON101 (FESPIXON®)
    Dermatology
    Diabetic Foot Ulcer

    ON101 is a first-in-class new drug targeting the subsets of macrophages to promote healing of the chronic wounds. It has been demonstrated with the superior efficacy to the standard care dressing in a Phase 3 MRCT completed in the US, Taiwan, and China. It has been marketed under the trade name FESPIXON® in Taiwan since June 2021 and been granted the Fast Track designation by the US FDA in March 2021. Multiple NDA submissions of ON101 to Asian health authorities are underway

  • FB825
    Dermatology
    Immunology
    Atopic Dermatitis
    Allergic Asthma

    FB825 is a first-in-class antibody targeting IgE B cells for the treatment of allergic diseases. It specifically binds to the CεmX domain on the membrane-bound IgE B cells and induces the apoptosis and ADCC of the targeted cells

  • FB704A
    Immunology
    Severe Asthma
    Chronic Kidney Disease

    FB704A is an innovative monoclonal antibody drug that neutralizes IL-6. By inhibiting both the classical and trans-signaling pathways of IL-6, it explores the improvement of symptoms in severe neutrophilic asthma.

  • OB318
    Immunology
    Cancer (e.g., liver cancer)

    OB318 is a new drug for hepatocellular carcinoma (HCC) which is the most common type of liver cancers, accounting for 90% of the cases

  • SNS812
    Infection
    Pan-COVID

    SNS812 is a first-in-class siRNA new drug for COVID-19 infection. It specifically targets the highly conserved region of SARS-COV-2 genome to inhibit virus replication and eliminate viruses in cells.           

  • SNS851
    Metabolism
    Weight loss
    Metabolism diseases

    SNS851 is an innovative siRNA drug for weight loss and improving metabolism-related markers. Efficacy data from mouse studies showed that even under a high-fat diet, mice exhibited increased basal metabolic rate, no weight gain, reduced fat accumulation, improvement in the severity of fatty liver, significant improvements in blood lipids and blood glucose markers, and no reduction in muscle mass, indicating that the mice became healthier.

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